What comes first, “the chicken or the egg?”. Understanding the Pharmacokinetics (PK) [Absorption, Distribution, Metabolism, and Excretion] of your test material/drug is a key critical step in preclinical drug development. In the early phases of developing therapeutics, having quick and reliable PK data is crucial for making informed go-no go decisions on the fate of your test substance/drug. At Attentive Science, we understand the unique challenges you face—whether it's managing tight timelines, optimizing absorption, or delivering defendable data that advances your program with confidence

We have a dedicated team of experienced drug discovery scientists that specialize in all things pharmacokinetics. For example: high-throughput pharmacokinetic (HTPK) studies are routinely conducted at Attentive Science in all test systems with a single lead candidate or numerous test materials/formulations to efficiently generate large quantities of PK data in a relatively short time. The primary objective of these studies is to streamline the development pipeline driven by quality PK data, allowing for multiple formulations, test materials/compounds, or dosing strategies to be deployed, which significantly reduces time and cost. We offer a suite of PK services designed to address the complexities of “druggability” evaluation.

A Commitment to Quality and Speed

Once a lead candidate is selected, continued safety evaluation of the test material/drug is required before it can be included into a regulatory submission, which can be time consuming. Attentive Science has honed the concept of “immediate start” in our discovery and toxicology/safety departments with flexible room configurations in two separate buildings to meet the demand of the industry. Our approach cuts off your drug development timeline by initiating studies within 2-4 weeks, while maintaining the highest quality data; thus, saving valuable days/weeks. Unlike larger Contract Research Organizations (CROs), where lack of attention and long queues can delay critical studies, Attentive Science stands apart with personalized attention, rapid turnaround times, and a steadfast focus on quality. Our team, built on decades of collective experience, ensures your project is handled by experts who bring reliability and precision to every stage.

Value-Driven Strategies for Success

What preceded the other—the chicken or the egg? and how are they interconnected. Attentive Science is set up to allow our clients to initiate PK studies quickly and generate data in an accelerated manner, which in-turn expediates the decision-making processes. The PK data generated from these studies is important to support dose level selection on dose-ranging and GLP toxicology studies. Furthermore, on your IND-enabling studies, having high quality and reliable PK data is paramount for the safety evaluation of the test material/drug, which will be used to establish the Clinical Trial safety margins based on the preclinical no-observed-adverse-effect-level (NOAEL) and correlating PK parameters.

Your Partner in Progress

Whether you’re assessing a single test material / drug or managing multiple test materials, Attentive Science is committed to meeting you where you are in your development cycle. We thrive on providing tailored solutions, ensuring every project is executed with the highest level of care, attention, and scientific rigor.

Let Attentive Science be your partner in navigating the complexities of PK and formulation screening. Together, we can unlock the potential of your therapeutic agents and pave the way for innovative, patient-centric drug solutions. Contact Us