Creative Writer Let's Take a Breath and Discuss Something... A previous blog from Attentive Science provided an overview of the core battery Safety Pharmacology assessments required prior to first administration of new drugs to humans. In this issue we will dis... Jul 13, 2021
Creative Writer In-vivo Cardiovascular Safety (CV) Assessments from Attentive Science A crucial regulatory step for development and approval of test substances that have high systemic exposure is Safety Pharmacology. Prior to phase I clinical trials, the effects of a therapeutic on the... Jun 25, 2021
Creative Writer Go to the front of the line - with Attentive Post the “Covid 19 lockdown state of affairs” of 2020 we have seen that many of the companies for whom we provide services are looking to return to “normal” situations with regards to drug development... Jun 13, 2021
Creative Writer Program Timelines at Attentive Science The quality and scientific expertise of veterans at Attentive Science remains unquestionable for Pharmacokinetics, Toxicology and Safety Pharmacology. Another very important attribute required in our ... May 29, 2021
Creative Writer CNS Safety Pharmacology Services from Attentive Science A previous blog from Attentive Science provided an overview of the core battery Safety Pharmacology assessments required prior to first administration of new drugs to humans. In this issue we will dis... May 15, 2021
Creative Writer ...to SEND or not to SEND... Recent expedited U.S. Food & Drug Administration (FDA) review in response to our public health emergency demonstrates efficiencies that can be attained with true implementation of standardized data. I... Apr 30, 2021
Creative Writer Long Term Pharmacokinetic Studies Typically, drugs have a relatively short half-life. Every once in a while, a drug will be under development that has a significantly longer half-life than the norm. These “unicorn” compounds might be ... Apr 12, 2021
Creative Writer Safety Pharmacology at Attentive Science Safety Pharmacology assessments have been a required component of the IND submission package since 2001 per ICH guidelines S7A/B. These studies are designed to tease out the potential for adverse even... Mar 29, 2021
Creative Writer Maximum Tolerated Dose (MTD) Studies Maximum Tolerated Dose (MTD) studies are among one of the earliest opportunities to administer your compound to a living test system, in order to determine potential signs of toxicity. Establishing th... Mar 11, 2021
Creative Writer Subchronic Toxicology Studies from Attentive Subchronic toxicology studies are regulatory driven studies necessary to properly assess the toxicity and toxicokinetic profile of your compound that will be used to establish equivalent doses on your... Feb 25, 2021
Creative Writer High Throughput Non-Rodent In-Vivo PK Your compounds that are destined for success and ultimately reaching your intended target population need to blossom. Eliminating compounds that have less desirable and/or poor In-Vivo Pharmacokinetic... Feb 10, 2021
Creative Writer Dose Range Finding Studies From Attentive When working with an experienced lab, Dose Range Finding (DRF) studies are used as an early detection warning system for your compound. Typically in DRF studies we are pushing dose levels to identify ... Jan 25, 2021