Creative Writer Go to the front of the line - with Attentive Post the “Covid 19 lockdown state of affairs” of 2020 we have seen that many of the companies for whom we provide services are looking to return to “normal” situations with regards to drug development... Jun 7, 2021
Creative Writer Program Timelines at Attentive Science The quality and scientific expertise of veterans at Attentive Science remains unquestionable for Pharmacokinetics [1] , Toxicology [2] and Safety Pharmacology [3] . Another very important attribute r... May 25, 2021
Creative Writer CNS Safety Pharmacology Services from Attentive Science A previous blog [1] from Attentive Science provided an overview of the core battery Safety Pharmacology assessments required prior to first administration of new drugs to humans. In this issue we will... May 12, 2021
Creative Writer ...to SEND or not to SEND... Recent expedited U.S. Food & Drug Administration (FDA) review in response to our public health emergency demonstrates efficiencies that can be attained with true implementation of standardized data. ... Apr 28, 2021
Creative Writer Long Term Pharmacokinetic Studies Typically, drugs have a relatively short half-life. Every once in a while, a drug will be under development that has a significantly longer half-life than the norm. These “unicorn” compounds might be ... Apr 14, 2021
Creative Writer Safety Pharmacology at Attentive Science Safety Pharmacology assessments have been a required component of the IND submission package since 2001 per ICH guidelines S7A/B. These studies are designed to tease out the potential for adverse... Mar 24, 2021
Creative Writer Maximum Tolerated Dose (MTD) Studies Maximum Tolerated Dose (MTD) studies are among one of the earliest opportunities to administer your compound to a living test system, in order to determine potential signs of toxicity. Establishing th... Mar 10, 2021
Creative Writer Subchronic Toxicology Studies from Attentive Subchronic toxicology studies are regulatory driven studies necessary to properly assess the toxicity and toxicokinetic profile of your compound that will be used to establish equivalent doses on your... Feb 25, 2021
Creative Writer High Throughput Non-Rodent In-Vivo PK Your compounds that are destined for success and ultimately reaching your intended target population need to blossom. Eliminating compounds that have less desirable and/or poor In-Vivo Pharmacokin... Feb 10, 2021
Creative Writer Dose Range Finding Studies From Attentive When working with an experienced lab, Dose Range Finding (DRF) studies are used as an early detection warning system for your compound. Typically in DRF studies we are pushing dose levels to identify... Jan 27, 2021
Creative Writer Continuing Collaboration, Oversight and Accountability You have spent time and money developing a compound and selecting a contract research lab to help develop that compound into a marketable therapy. You are now at the point where you have to hand that ... Jan 13, 2021
Creative Writer IND Enabling Studies from Attentive Science Investigational New Drug (IND) enabling studies are a matrix of tests that must be conducted before a new therapeutic can be administered to the intended population. Depending on the results of each I... Dec 15, 2020